Czech J. Food Sci., 2008, 26(6):393-401 | DOI: 10.17221/2438-CJFS

Screening methods used for the detection of veterinary drug residues in raw cow milk - a review

Pavlína Navrátilová
Department of Milk Hygiene and Technology, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences in Brno, Brno, Czech Republic

At both national and international levels, increasing attention is paid to the evaluation of the risk of occurrence of veterinary drug residues in foodstuffs and foods of animal origin, and to the introduction of appropriate measures to reduce this risk. The design and strategy of antibiotics and sulphonamide detection in milk involve two different aspects: the ability to sell the milk depending on its quality (technological safety), and the health safety of the milk regulated by the recent legislative regulations (toxicological safety). Veterinary drug residues in milk represent a health risk for the consumer. This review describes the methods used for extensive monitoring of antimicrobial agents - microbial inhibitor methods and rapid specific assays.

Keywords: antibiotics; residues; methods

Published: December 31, 2008  Show citation

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Navrátilová P. Screening methods used for the detection of veterinary drug residues in raw cow milk - a review. Czech J. Food Sci. 2008;26(6):393-401. doi: 10.17221/2438-CJFS.
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    References

    1. Althaus R.L., Torres A., Montero A., Balash S., Molina M.P. (2003): Detection limits of antimicrobials in ewe milk by delvotest photometric measurements. Journal of Dairy Science, 86: 457-463. Go to original source... Go to PubMed...
    2. Andrew S.M. (2001): Effect of composition of colostrum and transition milk from holstein heifers on specificity rates of antibiotic residue tests. Journal of Dairy Science, 84: 100-106. Go to original source... Go to PubMed...
    3. Angelidis A.S., Farver B.T., Cullor J.S. (1999): Evaluation of the Delvo-X-Press assay for detecting antibiotic residues in milk samples from individual cows. Journal of Food Protection, 62: 1183-1190. Go to original source... Go to PubMed...
    4. Bell C., Rhoades J.R., Neaves P., Scannella D. (1995): An evaluation of the IDEXX SNAP test for the detection of beta-lactam antibiotics in ex-farm raw milks. Netherlands Milk and Dairy Journal, 49: 15-25.
    5. Botsoglou N.A., Fletouris D.J. (2001): Drug Residues in Foods, Pharmacology, Food Safety, and Analysis. Marcel Dekker, New York.
    6. Carlsson A., Bjorck L., Persson K. (1989): Lactoferrin and lysozyme in milk during acute mastitis and their inhibitory effect in Delvotest P. Journal of Dairy Science, 72: 3166-3175. Go to original source... Go to PubMed...
    7. Commission Regulation (EC) No 1662/2006 of 6 November 2006 amending Regulation (EC) No 853/2004 of the European Parliament and of the Council laying down specific hygiene rules for food of animal origin. Official Journal of the European Union, L 320, 18.11.2006.
    8. Council Regulation (EEC) No 2377/90 of 26 June 1990 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin. Official Journal of the European Union, L 224, 18.8.1990.
    9. Cullor J.S. (1993): Antibiotic Residue Tests for Mammary Gland secretions. The Veterinary Clinics of North America. Food Animal Practice, 9: 609-620. Go to original source... Go to PubMed...
    10. Cullor J.S., Van Eenennaam A., Dellinger J., Perani L., Smith W., Jensen L. (1992): Antibiotic residue assays: Can they be used to test milk from individual cows? Veterinary Medicine, 87: 477-494.
    11. Fischer W.J., Tritscher A.M., Schilter B., Stadler R.H. (2003): Contaminants resulting from agricultural and dairy practices. In: Roginski H.: Encyclopedia of Dairy Sciences. Vol. 1. Elsevier Science, London: 516-525. Go to original source...
    12. Frére J.M., Leyh-Bouille M., Ghuysen J.M., Nieto M., Perkins H.R. (1976): Exocellular DD-carboxypeptidases-transpeptidases from Streptomyces. Methods in Enzymology, 45: 610-636. Go to original source... Go to PubMed...
    13. Ghuysen J.M. (1977): The concept of the penicillin target from 1965 until today. Journal of General Microbiology, 101: 13-33. Go to original source... Go to PubMed...
    14. Ghuysen J.M. (1991): Serine β-lactamases and penicillin-binding proteins. Annual Review of Microbiology, 45: 37-67. Go to original source... Go to PubMed...
    15. Ghuysen J.M., Leyh-Bouille M., Campbell J.N., Moreno R., Frére J.M., Duez C., Nieto M., Perkins H.R. (1973): Structure of the wall peptidoglycan of streptomyces R39 and the specifity profile of its exocellular DD-carboxypeptidase-transpeptidase for peptide acceptors. Biochemistry, 12: 1243-1251. Go to original source... Go to PubMed...
    16. Granier B., Jamin M., Adam M., Galleni M., Lakaye B., Zorzi W., Grandchamps J., Wilkin J.M., Fraipont C., Joris B., Duez C., Nguyendisteche M., Coyette J., Leyhbouille M., Dusart J., Christiaens L., Frére J.M., Ghuysen J.M. (1994): Proteolytic Enzymes: Serine and Cysteine Peptidases, Vol. 244. Academic Press Inc., San Diego: 249-266. Go to original source...
    17. Gustavsson E. (2003): SPR Biosenzor Analysis of β-Lactam Antibiotics in Milk. [Doctoral Thesis.] SLU Service/Repro, Uppsala.
    18. Gustavsson E., Sternesjö Å. (2004): Biosensor analysis of β-lactams in milk: comparison with microbiological, immunological, and receptor-based screening methods. Journal of AOAC International, 87: 614-620. Go to original source... Go to PubMed...
    19. Heeschen W.H. (1993): Residues of antibiotics and sulfonamides in milk. Bulletin of the IDF No 283/1993. International Dairy Federation, Brussel: 3-13.
    20. Heeschen W.H., Blüthgen A. (1991): Veterinary drugs and pharmacologically active compounds. Monograph on residues and contaminants in milk and milk products. IDF, Brussel: 13-69.
    21. Herrman J.L. (1995): Codex Alimentarius and assessments of residues of veterinary drugs by FAO and WHO: Concepts and strategies. In: Symposium on Residues of Antimicrobial Drugs and other Inhibitors in Milk. Kiel, Germany. International Dairy Federation, Brussel: 107-114.
    22. Honkanen-Buzalski T., Reybroeck W. (1997): Antimicrobials. Monograph on Residues and Contaminants in Milk and Milk Products. IDF Special Issue 9701. International Dairy Federation, Brussel: 26-33.
    23. Honkanen-Buzalski T., Suhren G. (1999): Residues of antimicrobial agents in milk and their significance to public health and milk processing. Bulletin IDF No 345. International Dairy Federation, Brussel: 11-12.
    24. Hui Y.H. (1993): Dairy Science and Technology Handbook. John Wiley & Sons, New York.
    25. Kang J.H., Kondo F. (2001): Occurrence of false-positive results of inhibitor on milk samples using the Delvotest SP assay. Journal of Food Protection, 64: 1211-1215. Go to original source... Go to PubMed...
    26. Kang J.H., Jin J.H., Kondo F. (2005): False-positive outcome and drug residue in milk samples over withdrawal times. Journal of Dairy Science, 88: 908-913. Go to original source... Go to PubMed...
    27. Katz S.E., Siewierski M. (1995): Bacillus stearothermophilus disc assay: a rewiev. Journal of AOAC International, 78: 1408-1415. Go to original source...
    28. Leyh-Bouille M., Ghuysen J.M., Bonaly R., Nieto M., Perkins H.R., Schleifer K.H., Kandler O. (1970): Substrate requirements of the Streptomyces albus G DD-carboxypeptidase. Biochemistry, 9: 2961-2970. Go to original source... Go to PubMed...
    29. Massova I., Mobashery S. (1998): Kinship and diversification of bacterial penicillin-binding proteins and β-lactamases. Antimicrobial Agents and Chemotherapy, 42: 1-17. Go to original source... Go to PubMed...
    30. Mäyrä-Mäkinen A. (1995): Technological significance of residues for the dairy industry. In: Symposium on Residues of Antimicrobial Drugs and Other Inhibitors in Milk. IDF Special Issue No. 95 05. Kiel, Germany: 136-143.
    31. Mitchell J.M., Griffiths M.W., McEwen S.A., McNab W.B., Yee A.J. (1998): Antimicrobial drug residues in milk and meat: cause, concerns, prevalence, regulations, tests, and test performance. Journal of Food Protection, 61: 742-756. Go to original source... Go to PubMed...
    32. Neaves P. (1995): An evaluation of the IDEXX SNAP test for detecting β-lactam antibiotics in raw milk. In: Symposium on Residues of Antimicrobial Drugs and Other Inhibitors in Milk. IDF Special Issue No. 95 05. Kiel, Germany: 239-243.
    33. Regulation (EC) No 1831/2003 of the European Parliament and of the Council of 22 September 2003 on additives for use in animal nutrition. Official Journal of the European Union, L 268, 18.10.2003: 0029-0043.
    34. Roeder A.M., Roeder M. (2000): Antibiotics in foods of animal origin. In: Francis F.: Encyclopedia of Food Science and Technology. Vol. 1, 2nd Ed. John Wiley & Sons Inc., New York: 54-63.
    35. Stepaniak L., Sørhaug T., Jedrychowski L. (2003): Immunochemical. In: Roginski H.: Encyclopedia of Dairy Sciences. Vol. 1. Elsevier Science Ltd., London: 62-66. Go to original source...
    36. Sternesjö Å., Johnsson G.A. (1998): Novel rapid enzyme immunoassay (Fluorophos Beta Screen) for detection of β-lactam residues in ex-farm raw milk. Journal of Food Protection, 61: 808-811. Go to original source...
    37. Suhren G. (1995): Possibilities and limitations of microbiological inhibitor tests. In: Symposium on Residues of Antimicrobial Drugs and Other Inhibitors in Milk. IDF Special Issue No. 95 05. Kiel, Germany. IDF, Brussel: 159-171.
    38. Van Herwijnen R. (2006): The use of lateral flow device to detect food allergens. In: Koppelman J, Helfe S.L.: Detecting Allergens in Food. Woodhead Publishing, Cambridge: 175-181. Go to original source...

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