Czech J. Food Sci., 2005, 23(5):202-208 | DOI: 10.17221/3392-CJFS

Antimutagenic effect of resveratrol

Martina Langová1, Zdeňka Polívková1, Petr ©merák1, Jiřina Bártová2, Ivo Bárta1
1 Department of General Biology and Genetics, Center of Biomedical Science and
2 Department of General Hygiene, Center of Preventive Medicine, 3 rd Faculty of Medicine, Charles University, Prague, Czech Republic

Evidence exists from population-based and laboratory studies that some phytochemicals have protective effects against tumors or other diseases and reveal antimutagenic activity. We studied the protective effect of the plant phytoallexin resveratrol on the mutagenic activity of three mutagens, i.e. aflatoxin B1 (AFB1), 2-amino-3-methylimidazo[4,5-f]qui-noline (IQ) and N-nitroso-N-methylurea (MNU) using the Ames and the micronucleus tests. In the Ames test, we proved a significant antimutagenic activity only against the indirect mutagens AFB1 and IQ, not against the direct mutagen MNU. A significant decrease of mutagenicity of all three mutagens was detected by the micronucleus test.

Keywords: resveratrol; aflatoxin B1; 2-amino-3-methylimidazo[4,5-f]quinoline; N-nitroso-N-methylurea

Published: October 31, 2005  Show citation

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Langová M, Polívková Z, ©merák P, Bártová J, Bárta I. Antimutagenic effect of resveratrol. Czech J. Food Sci. 2005;23(5):202-208. doi: 10.17221/3392-CJFS.
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