Czech J. Food Sci., 2001, 19(3):90-96 | DOI: 10.17221/6583-CJFS

Mutagenic effects of selected trichothecene mycotoxins and their combinations with aflatoxin B1

P. ©merák, I. Bárta, Z. Polívková, J. Bártová, M. Sedmíková
1 3rd Medical Faculty, Charles University, Prague; Czech Agricultural University, Prague, Czech Republic

The authors focused on the amplification of data on the mutagenicity of selected trichothecene mycotoxins (T-2 toxin, vomitoxin) and their combination with aflatoxin B1,which is known to be a strong mutagen. Mutagenic activity was investigated using the Ames test in a prokaryote model at low doses (close to 0.1 LD50). Whereas the individual trichothecene mycotoxins (T-2 toxin, vomitoxin) did not show any mutagenic activity in the test systems mentioned, in combination with AFB1, or as a combination of all three mycotoxins, they showed a mutagenic effect significantly greater than AFB1 alone in the Ames test (in strain TA98 at all concentrations) as well as in the micronucleus test (combination of T-2 toxin with AFB1).

Keywords: mutagenic activity; Ames test; micronucleus test; mycotoxins; aflatoxin B1; T-2 toxin; vomitoxin

Published: June 30, 2001  Show citation

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©merák P, Bárta I, Polívková Z, Bártová J, Sedmíková M. Mutagenic effects of selected trichothecene mycotoxins and their combinations with aflatoxin B1. Czech J. Food Sci. 2001;19(3):90-96. doi: 10.17221/6583-CJFS.
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