Czech J. Food Sci., 2001, 19(3):81-84 | DOI: 10.17221/6581-CJFS

Antioxidant activity of 2,6-dimethyl-3,5-dialkoxycarbonyl-1,4-dihydropyridines in metal-ion catalyzed lipid peroxidation

G. Tirzitis, D. Tirzite, Z. Hyvonen
Latvian Institute of Organic Synthesis, Riga, Latvia

Antioxidants with 1,4-dihydropyridine structure were investigated as a less harmful alternative to synthetic phenolic antioxidants in liposomes under conditions simulating food storage. The antioxidant activities (AOA) of 2,6-dimethyl-3,5-dialkoxycarbonyl-1,4-dihydropyridines possessing various side chain length alkyls (CH3 - C16H33) in ester moiety were tested in transition metal-ion catalyzed liposome peroxidation and compared with AOA of Trolox™ and Probucol™. The compounds with C2H5 - C4H9 residues in the 3,5-position ester moieties exert the most pronounced AOA. The AOA of tested compounds is associated with their ability to incorporate into liposomes.

Keywords: 1,4-dihydropyridines; antioxidants; metal-ion catalyzed peroxidation

Published: June 30, 2001  Show citation

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Tirzitis G, Tirzite D, Hyvonen Z. Antioxidant activity of 2,6-dimethyl-3,5-dialkoxycarbonyl-1,4-dihydropyridines in metal-ion catalyzed lipid peroxidation. Czech J. Food Sci. 2001;19(3):81-84. doi: 10.17221/6581-CJFS.
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